KMID : 1007520180270041185
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Food Science and Biotechnology 2018 Volume.27 No. 4 p.1185 ~ p.1192
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Effect of oral administration of ¥â-glucans derived from Aureobasidium pullulans SM-2001 in model mice and rat with atopic dermatitis-like phenotypes
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Kim In-Sung
Lee Seung-Ho Kim Jeong-A Yu Da-Yoon Hong Yeon-Hee Kim Jae-Young Lim Jong-Min Lee Sang-Suk Yun Cheol-Heui Choi In-Soon Cho Kwang-Keun
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Abstract
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In this study, we investigated the anti-atopic dermatitis (AD) activity of ¥â-glucans derived from Aureobasidium pullulans SM-2001 (¥âGdAP). ¥âGdAP was orally administered to AD animal models such as vasodilation, allergic pruritus and contact dermatitis. Administration of ¥âGdAP attenuated the amount of Evans blue solution on vasodilation rat. Scratching behaviors, secretion of histamine and ear thickness were significantly (p < 0.05) attenuated in the ¥âGdAP-treated mouse groups. Interestingly, transcriptional expression of T-bet, a transcription factor for Th1 reactions, was increased, but that of GATA-3, a transcription factor for Th2 reactions, was attenuated in the ¥âGdAP-treated groups (p < 0.05). In addition, we found that reduced transcriptional expression of forkhead box P3 and galectin-9, regulators of regulatory T cells, was recovered in the ¥âGdAP-treated groups (p < 0.05). Taken together, these data indicate that administration of ¥âGdAP could effectively attenuate AD-like phenotypes via regulation of Th1/Th2 transcriptional activity and Treg activation.
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KEYWORD
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¥â-Glucan, Aureobasidium pullulans SM-2001, Atopic dermatitis, Th1/Th2, FOXP3, Galectin-9
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